Acknowledging the receipt of letters and works by Humboldt; discussing the Mexican War of Independence and the future of "New Spain"; writing about the concept of an "American hemisphere" with a "separate system of interests, which must not be subordinated to those of Europe"; discussing the future of the United States; writing at length about the American policy of extermination and genocide towards Native peoples; describing the English as having "seduced the greater part of the tribes" and drawing connections to English imperialism in Asia and Ireland; acknowledging that Zebulon Pike used Humboldt's maps of Spanish America without his permission, but asking Humboldt to forgive Pike as "a deceased hero"; writing about the delay in the publication of the narrative of Lewis and Clark's journey to the Pacific; promising to send Humboldt the tobacco seed he desires.